TY - JOUR
T1 - Improving the Compatibility of Diketopyrrolopyrrole Semiconducting Polymers for Biological Interfacing by Lysine Attachment
AU - Du, Weiyuan
AU - Ohayon, David
AU - Combe, Craig
AU - Mottier, Lorene
AU - Maria, Iuliana P.
AU - Ashraf, Raja S.
AU - Fiumelli, Hubert
AU - Inal, Sahika
AU - McCulloch, Iain
N1 - Publisher Copyright:
Copyright © 2018 American Chemical Society.
PY - 2018/9/11
Y1 - 2018/9/11
N2 - Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged, and low-surface energy semiconducting thin films limits their use as part of in vitro, cell-integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole semiconducting polymer on neural cell adhesion and growth and evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need for biological coating steps while changing the surface physiochemistry, which makes them promising for applications in bioelectronics.
AB - Organic semiconductors are being increasingly used for a variety of biological applications, such as biochemical sensors, drug delivery, and neural interfaces. However, the poor adhesion of cells to the typically hydrophobic, neutrally charged, and low-surface energy semiconducting thin films limits their use as part of in vitro, cell-integrated bioelectronic devices. In this work, we investigate the influence of lysine side chain units incorporated in a diketopyrrolopyrrole semiconducting polymer on neural cell adhesion and growth and evaluate their function in electrical devices. Synthesis of such biofunctionalized polymers obviates the need for biological coating steps while changing the surface physiochemistry, which makes them promising for applications in bioelectronics.
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U2 - 10.1021/acs.chemmater.8b02804
DO - 10.1021/acs.chemmater.8b02804
M3 - Article
AN - SCOPUS:85052908134
SN - 0897-4756
VL - 30
SP - 6164
EP - 6172
JO - Chemistry of Materials
JF - Chemistry of Materials
IS - 17
ER -