Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening

Mark A. Huffman, Paul J. Reider

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

A multidimensional screening of catalysts and additives led to the discovery of improved conditions for the diastereoselective reductive amination which produces enalapril. Additives acetic acid and potassium fluoride, which in isolation are detrimental, work together to improve the SSS: RSS selectivity with Ra-Ni in ethanol to 17: 1 from 11: 1.

Original languageEnglish (US)
Pages (from-to)831-834
Number of pages4
JournalTetrahedron Letters
Volume40
Issue number5
DOIs
StatePublished - Jan 29 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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