Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening

Mark A. Huffman; Paul J. Reider

doi:10.1016/S0040-4039(98)02590-8

Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening

Mark A. Huffman, Paul J. Reider

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

A multidimensional screening of catalysts and additives led to the discovery of improved conditions for the diastereoselective reductive amination which produces enalapril. Additives acetic acid and potassium fluoride, which in isolation are detrimental, work together to improve the SSS: RSS selectivity with Ra-Ni in ethanol to 17: 1 from 11: 1.

Original language	English (US)
Pages (from-to)	831-834
Number of pages	4
Journal	Tetrahedron Letters
Volume	40
Issue number	5
DOIs	https://doi.org/10.1016/S0040-4039(98)02590-8
State	Published - Jan 29 1999
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(98)02590-8

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title = "Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening",

abstract = "A multidimensional screening of catalysts and additives led to the discovery of improved conditions for the diastereoselective reductive amination which produces enalapril. Additives acetic acid and potassium fluoride, which in isolation are detrimental, work together to improve the SSS: RSS selectivity with Ra-Ni in ethanol to 17: 1 from 11: 1.",

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AU - Reider, Paul J.

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N2 - A multidimensional screening of catalysts and additives led to the discovery of improved conditions for the diastereoselective reductive amination which produces enalapril. Additives acetic acid and potassium fluoride, which in isolation are detrimental, work together to improve the SSS: RSS selectivity with Ra-Ni in ethanol to 17: 1 from 11: 1.

AB - A multidimensional screening of catalysts and additives led to the discovery of improved conditions for the diastereoselective reductive amination which produces enalapril. Additives acetic acid and potassium fluoride, which in isolation are detrimental, work together to improve the SSS: RSS selectivity with Ra-Ni in ethanol to 17: 1 from 11: 1.

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 5

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Improved stereoselectivity in the heterogeneous catalytic synthesis of enalapril obtained through multidimensional screening

Abstract

All Science Journal Classification (ASJC) codes

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