Impact of diversity of morphological characteristics and Reynolds number on local hemodynamics in basilar aneurysms

Marjan Rafat, Howard A. Stone, Debra T. Auguste, Mahsa Dabagh, Amanda Randles, Martin Heller, James D. Rabinov

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Morphological and hemodynamic parameters have been suggested to affect the rupture of cerebral aneurysms, but detailed mechanisms of rupture are poorly understood. The purpose of our study is to determine criteria for predicting the risk of aneurysm rupture, which is critical for improved patient management. Existing aneurysm hemodynamics studies generally evaluate limited geometries or Reynolds numbers (Re), which are difficult to apply to a wide range of patient-specific cases. Association between hemodynamic characteristics and morphology is focused. Several two-dimensional (2D) and three-dimensional (3D) idealized and physiological geometries is assessed to characterize the hemodynamic landscape between flow patterns. The impact of morphology on velocity and wall shear stress (WSS) profiles were evaluated. Slight changes in aneurysm geometry is found or Re result in significant changes in the hemodynamic and WSS profiles. Our systematic mapping and nondimensional analysis qualitatively identify hemodynamic conditions that may predispose aneurysms to rupture.

Original languageEnglish (US)
Pages (from-to)2792-2802
Number of pages11
JournalAIChE Journal
Volume64
Issue number7
DOIs
StatePublished - Jul 2018

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Environmental Engineering
  • Chemical Engineering(all)

Keywords

  • aneurysm geometry
  • computational fluid dynamics
  • flow patterns
  • hemodynamics
  • wall shear stress

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