Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report

Jennifer Cable, Jeffrey C. Rathmell, Erika L. Pearce, Ping Chih Ho, Marcia C. Haigis, Murad R. Mamedov, Meng Ju Wu, Susan M. Kaech, Lydia Lynch, Mark A. Febbraio, Sagar P. Bapat, Hanna S. Hong, Weiping Zou, Yasmine Belkaid, Zuri A. Sullivan, Andrea Keller, Stefanie K. Wculek, Douglas R. Green, Catherine Postic, Ido AmitSalvador Aznar Benitah, Russell G. Jones, Miguel Reina-Campos, Santiago Valle Torres, Semir Beyaz, Donal Brennan, Luke A.J. O'Neill, Rachel J. Perry, Dirk Brenner

Research output: Contribution to journalArticlepeer-review

Abstract

Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells that affect their function or the impact of immune cells on systemic metabolism. A more holistic approach that considers both these viewpoints is needed. On September 5–8, 2022, experts in the field of immunometabolism met for the Keystone symposium “Immunometabolism at the Crossroads of Obesity and Cancer” to present recent research across the field of immunometabolism, with the setting of obesity and cancer as an ideal example of the complex interplay between metabolism, immunity, and cancer. Speakers highlighted new insights on the metabolic links between tumor cells and immune cells, with a focus on leveraging unique metabolic vulnerabilities of different cell types in the tumor microenvironment as therapeutic targets and demonstrated the effects of diet, the microbiome, and obesity on immune system function and cancer pathogenesis and therapy. Finally, speakers presented new technologies to interrogate the immune system and uncover novel metabolic pathways important for immunity.

Original languageEnglish (US)
Pages (from-to)38-50
Number of pages13
JournalAnnals of the New York Academy of Sciences
Volume1523
Issue number1
DOIs
StatePublished - May 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • History and Philosophy of Science

Keywords

  • cancer
  • immunity
  • immunometabolism
  • immunotherapy
  • metabolism
  • obesity

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