Immunoepidemiology of lymphatic filariasis: the relationship between infection and disease

Donald A.P. Bundy; Bryan T. Grenfell; P. K. Rajagopalan

doi:10.1016/0169-4758(91)90038-P

Immunoepidemiology of lymphatic filariasis: the relationship between infection and disease

Donald A.P. Bundy, Bryan T. Grenfell, P. K. Rajagopalan

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34 Scopus citations

Abstract

Lymphatic filariasis is manifested by a spectrum of symptoms that range from micro filaraemia to gross immunopathology. The geographical variations seen in this disease have been explained by heterogeneity in genetically determined host responses. By modelling the disease through time, Don Bundy, Bryan Grenfell and P.K. Rajagopalan can provide a simple, unified explanation for the observed heterogeneity. Their model shows that there is a sequential progression from infection, micro filaraemia, amicro filaraemia to obstructive disease in all individuals who experience micro filaraemia. Only the probability of developing micro filaraemia is geographically variable, being dependent on the local incidence of infection.

Original language	English (US)
Pages (from-to)	71-75
Number of pages	5
Journal	Parasitology Today
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0169-4758(91)90038-P
State	Published - Mar 1991
Externally published	Yes

All Science Journal Classification (ASJC) codes

Parasitology

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10.1016/0169-4758(91)90038-P

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title = "Immunoepidemiology of lymphatic filariasis: the relationship between infection and disease",

abstract = "Lymphatic filariasis is manifested by a spectrum of symptoms that range from micro filaraemia to gross immunopathology. The geographical variations seen in this disease have been explained by heterogeneity in genetically determined host responses. By modelling the disease through time, Don Bundy, Bryan Grenfell and P.K. Rajagopalan can provide a simple, unified explanation for the observed heterogeneity. Their model shows that there is a sequential progression from infection, micro filaraemia, amicro filaraemia to obstructive disease in all individuals who experience micro filaraemia. Only the probability of developing micro filaraemia is geographically variable, being dependent on the local incidence of infection.",

author = "Bundy, {Donald A.P.} and Grenfell, {Bryan T.} and Rajagopalan, {P. K.}",

year = "1991",

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AU - Rajagopalan, P. K.

PY - 1991/3

Y1 - 1991/3

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AB - Lymphatic filariasis is manifested by a spectrum of symptoms that range from micro filaraemia to gross immunopathology. The geographical variations seen in this disease have been explained by heterogeneity in genetically determined host responses. By modelling the disease through time, Don Bundy, Bryan Grenfell and P.K. Rajagopalan can provide a simple, unified explanation for the observed heterogeneity. Their model shows that there is a sequential progression from infection, micro filaraemia, amicro filaraemia to obstructive disease in all individuals who experience micro filaraemia. Only the probability of developing micro filaraemia is geographically variable, being dependent on the local incidence of infection.

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Immunoepidemiology of lymphatic filariasis: the relationship between infection and disease

Abstract

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