TY - JOUR
T1 - Immunoepidemiology of lymphatic filariasis
T2 - the relationship between infection and disease
AU - Bundy, Donald A.P.
AU - Grenfell, Bryan T.
AU - Rajagopalan, P. K.
PY - 1991
Y1 - 1991
N2 - Lymphatic filariasis is manifested by a spectrum of symptoms that range from microfilaraemia to gross immunopathology. The geographical variations seen in this disease have been explained by heterogeneity in genetically determined host responses. By modelling the disease through time, Don Bundy, Bryan Grenfell and P.K. Rafagopalan can provide a simple, unified explanation for the observed heterogeneity. Their model shows that there is a sequential progression from infection, microfilaraemia, amicrofilaraemia to obstructive disease in all individuals who experience microfilaraemia. Only the probability of developing microfilaraemia is geographically variable, being dependent on the local incidence of infection.
AB - Lymphatic filariasis is manifested by a spectrum of symptoms that range from microfilaraemia to gross immunopathology. The geographical variations seen in this disease have been explained by heterogeneity in genetically determined host responses. By modelling the disease through time, Don Bundy, Bryan Grenfell and P.K. Rafagopalan can provide a simple, unified explanation for the observed heterogeneity. Their model shows that there is a sequential progression from infection, microfilaraemia, amicrofilaraemia to obstructive disease in all individuals who experience microfilaraemia. Only the probability of developing microfilaraemia is geographically variable, being dependent on the local incidence of infection.
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U2 - 10.1016/S0167-5699(05)80021-0
DO - 10.1016/S0167-5699(05)80021-0
M3 - Article
C2 - 2069681
AN - SCOPUS:0025909093
SN - 1471-4906
VL - 12
SP - A71-A75
JO - Trends in Immunology
JF - Trends in Immunology
IS - 3
ER -