Immune Proteins in Brain Development and Synaptic Plasticity

Research output: Contribution to journalReview article

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Abstract

Many proteins first identified in the immune system are also expressed in the developing and adult nervous system. Unexpectedly, recent studies reveal that a number of these proteins, in addition to their immunological roles, are essential for the establishment, function, and modification of synaptic connections. These include proinflammatory cytokines (e.g., TNFα, IL-6), proteins of the innate immune system (e.g., complement C1q and C3, pentraxins, Dscam), members of the major histocompatibility complex class I (MHCI) family, and MHCI-binding immunoreceptors and their components (e.g., PIRB, Ly49, DAP12, CD3ζ). Understanding how these proteins function in neurons will clarify the molecular basis of fundamental events in brain development and plasticity and may add a new dimension to our understanding of neural-immune interactions in health and disease.

Original languageEnglish (US)
Pages (from-to)93-109
Number of pages17
JournalNeuron
Volume64
Issue number1
DOIs
StatePublished - Oct 15 2009

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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