Immune activation state modulates infant engram expression across development

Sarah D. Power, Erika Stewart, Louisa G. Zielke, Eric P. Byrne, Aaron Douglas, Clara Ortega De San Luis, Lydia Lynch, Tomás J. Ryan

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Infantile amnesia is possibly the most ubiquitous form of memory loss in mammals. We investigated how memories are stored in the brain throughout development by integrating engram labeling technology with mouse models of infantile amnesia. Here, we found a phenomenon in which male offspring in maternal immune activation models of autism spectrum disorder do not experience infantile amnesia. Maternal immune activation altered engram ensemble size and dendritic spine plasticity. We rescued the same apparently forgotten infantile memories in neurotypical mice by optogenetically reactivating dentate gyrus engram cells labeled during complex experiences in infancy. Furthermore, we permanently reinstated lost infantile memories by artificially updating the memory engram, demonstrating that infantile amnesia is a reversible process. Our findings suggest not only that infantile amnesia is due to a reversible retrieval deficit in engram expression but also that immune activation during development modulates innate, and reversible, forgetting switches that determine whether infantile amnesia will occur.

Original languageEnglish (US)
Article numberadg9921
JournalScience Advances
Volume9
Issue number45
DOIs
StatePublished - Nov 2023
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Fingerprint

Dive into the research topics of 'Immune activation state modulates infant engram expression across development'. Together they form a unique fingerprint.

Cite this