Imaging voltage-dependent cell motions with heterodyne Mach-Zehnder phase microscopy

Christopher Fang-Yen, Seungeun Oh, Yongkeun Park, Wonshik Choi, Sen Song, H. Sebastian Seung, Ramachandra R. Dasari, Michael S. Feld

Research output: Contribution to journalArticlepeer-review

51 Scopus citations


We describe a heterodyne Mach-Zehnder interferometric microscope capable of quantitative phase imaging of biological samples with subnanometer sensitivity and frame rates up to 10 kHz. We use the microscope to image cultured neurons and measure nanometer-scale voltage-dependent motions in cells expressing the membrane motor protein prestin.

Original languageEnglish (US)
Pages (from-to)1572-1574
Number of pages3
JournalOptics Letters
Issue number11
StatePublished - Jun 1 2007
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics


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