Imaging developmental cell cycles

Abraham Q. Kohrman, Rebecca P. Kim-Yip, Eszter Posfai

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The last decade has seen a major expansion in development of live biosensors, the tools needed to genetically encode them into model organisms, and the microscopic techniques used to visualize them. When combined, these offer us powerful tools with which to make fundamental discoveries about complex biological processes. In this review, we summarize the availability of biosensors to visualize an essential cellular process, the cell cycle, and the techniques for single-cell tracking and quantification of these reporters. We also highlight studies investigating the connection of cellular behavior to the cell cycle, particularly through live imaging, and anticipate exciting discoveries with the combination of these technologies in developmental contexts.

Original languageEnglish (US)
Pages (from-to)4149-4161
Number of pages13
JournalBiophysical Journal
Volume120
Issue number19
DOIs
StatePublished - Oct 5 2021

All Science Journal Classification (ASJC) codes

  • Biophysics

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