Imaging calcium dynamics in dendritic spines

Winfried Denk, Rafae Yuste, Karel Svoboda, David W. Tank

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Recent advances in optical imaging technology have enabled the measurement of Ca2+ dynamics in individual synaptic spines with high time resolution. Results from work using this new technology have confirmed the view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentration. In particular, the ability of Ca2+ to directly mediate Hebbian coincidence detection has been confirmed.

Original languageEnglish (US)
Pages (from-to)372-378
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Jun 1996
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General Neuroscience


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