Imaging calcium dynamics in dendritic spines

Winfried Denk; Rafae Yuste; Karel Svoboda; David W. Tank

doi:10.1016/S0959-4388(96)80122-X

Imaging calcium dynamics in dendritic spines

Winfried Denk, Rafae Yuste, Karel Svoboda, David W. Tank

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

Recent advances in optical imaging technology have enabled the measurement of Ca²⁺ dynamics in individual synaptic spines with high time resolution. Results from work using this new technology have confirmed the view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentration. In particular, the ability of Ca²⁺ to directly mediate Hebbian coincidence detection has been confirmed.

Original language	English (US)
Pages (from-to)	372-378
Number of pages	7
Journal	Current Opinion in Neurobiology
Volume	6
Issue number	3
DOIs	https://doi.org/10.1016/S0959-4388(96)80122-X
State	Published - Jun 1996
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

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10.1016/S0959-4388(96)80122-X

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title = "Imaging calcium dynamics in dendritic spines",

abstract = "Recent advances in optical imaging technology have enabled the measurement of Ca2+ dynamics in individual synaptic spines with high time resolution. Results from work using this new technology have confirmed the view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentration. In particular, the ability of Ca2+ to directly mediate Hebbian coincidence detection has been confirmed.",

author = "Winfried Denk and Rafae Yuste and Karel Svoboda and Tank, {David W.}",

year = "1996",

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T1 - Imaging calcium dynamics in dendritic spines

AU - Denk, Winfried

AU - Yuste, Rafae

AU - Svoboda, Karel

AU - Tank, David W.

PY - 1996/6

Y1 - 1996/6

N2 - Recent advances in optical imaging technology have enabled the measurement of Ca2+ dynamics in individual synaptic spines with high time resolution. Results from work using this new technology have confirmed the view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentration. In particular, the ability of Ca2+ to directly mediate Hebbian coincidence detection has been confirmed.

AB - Recent advances in optical imaging technology have enabled the measurement of Ca2+ dynamics in individual synaptic spines with high time resolution. Results from work using this new technology have confirmed the view that individual synaptic spines can act as functional chemical compartments with independent dynamics of second-messenger concentration. In particular, the ability of Ca2+ to directly mediate Hebbian coincidence detection has been confirmed.

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DO - 10.1016/S0959-4388(96)80122-X

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ER -

Imaging calcium dynamics in dendritic spines

Abstract

All Science Journal Classification (ASJC) codes

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