Identity crisis when telomeres left unprotected

Yun Wu, Virginia A. Zakian

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Loss of shelterin components TRF2 or POT1a-TPP1 complex from the chromosome end triggers DNA damage response (DDR) and aberrant DNA repair events. In a recent Nature paper, Chang and colleagues reported that the DNA repair protein Mre11 contributes to multiple events at the uncapped telomere, including ataxia telangiectasia-mutated (ATM)-dependent signaling, processing of the telomeric G-tail and homologous recombination (HR).

Original languageEnglish (US)
Pages (from-to)14-16
Number of pages3
JournalJournal of Molecular Cell Biology
Volume2
Issue number1
DOIs
StatePublished - 2010

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cell Biology

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