Abstract
Loss of shelterin components TRF2 or POT1a-TPP1 complex from the chromosome end triggers DNA damage response (DDR) and aberrant DNA repair events. In a recent Nature paper, Chang and colleagues reported that the DNA repair protein Mre11 contributes to multiple events at the uncapped telomere, including ataxia telangiectasia-mutated (ATM)-dependent signaling, processing of the telomeric G-tail and homologous recombination (HR).
Original language | English (US) |
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Pages (from-to) | 14-16 |
Number of pages | 3 |
Journal | Journal of Molecular Cell Biology |
Volume | 2 |
Issue number | 1 |
DOIs | |
State | Published - 2010 |
All Science Journal Classification (ASJC) codes
- Genetics
- Molecular Biology
- Cell Biology