Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner

Karthik Sambanthamoorthy, Ankush A. Gokhale, Weiwei Lao, Vijay Parashar, Matthew B. Neiditch, Martin F. Semmelhack, Ilsoon Lee, Christopher M. Waters

Research output: Contribution to journalArticle

62 Scopus citations

Abstract

Bacterial biofilm formation causes significant industrial economic loss and high morbidity and mortality in medical settings. Biofilms are defined as multicellular communities of bacteria encased in a matrix of protective extracellular polymers. Because biofilms have a high tolerance for treatment with antimicrobials, protect bacteria from immune defense, and resist clearance with standard sanitation protocols, it is critical to develop new approaches to prevent biofilm formation. Here, a novel benzimidazole molecule, named antibiofilm compound 1 (ABC-1), identified in a small-molecule screen, was found to prevent bacterial biofilm formation in multiple Gram-negative and Gram-positive bacterial pathogens, including Pseudomonas aeruginosa and Staphylococcus aureus, on a variety of different surface types. Importantly, ABC-1 itself does not inhibit the growth of bacteria, and it is effective at nanomolar concentrations. Also, coating a polystyrene surface with ABC-1 reduces biofilm formation. These data suggest ABC-1 is a new chemical scaffold for the development of antibiofilm compounds.

Original languageEnglish (US)
Pages (from-to)4369-4378
Number of pages10
JournalAntimicrobial Agents and Chemotherapy
Volume55
Issue number9
DOIs
StatePublished - Sep 2011

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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