Hydroxylation and Epoxidation Catalyzed by Iron-Porphine Complexes. Oxygen Transfer from Iodosylbenzene

John T. Groves, Thomas E. Nemo, Richard S. Myers

Research output: Contribution to journalArticle

849 Scopus citations

Abstract

The catalytic cycle of cytochrome P-450 is believed to involve reductive activation of dioxygen at the heme center andsubsequent peroxy bond clcavagc to give a ferry ion spccicsas the active oxygen transfer agent.1.2 Support for an iron-oxo species such as 1 is derived from the fact that a number of single oxygen donors, hydroperoxides, peroxy acids, and iodosylbenzcne, effect oxygen transfer in a manner similar inmany rcspccts to the fully reconstituted enzyme system.35 as part of our program to evaluate simple iron catalysts as oxygentransfer agents,6.7 we have found that chloro-α,β,γ,δ-tetra-phenylporphinatoiron(III) (2) and chlorodimethylferripro-toporphyrin IX (3) catalyze the hydroxylation and epoxidationof hydrocarbons with lodosvlbcnzene as an oxygen source.

Original languageEnglish (US)
Pages (from-to)1032-1033
Number of pages2
JournalJournal of the American Chemical Society
Volume101
Issue number4
DOIs
StatePublished - Feb 1 1979
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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