Hydrodynamic flow in a synaptic cleft during exocytosis

M. N. Shneider; R. S. Gimatdinov; A. I. Skorinkin; I. V. Kovyazina; E. E. Nikolsky

doi:10.1007/s00249-011-0759-3

Hydrodynamic flow in a synaptic cleft during exocytosis

M. N. Shneider, R. S. Gimatdinov, A. I. Skorinkin, I. V. Kovyazina, E. E. Nikolsky

Mechanical & Aerospace Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

It is shown that exocytosis in a chemical synapse may be accompanied by "microjet" formation due to the overpressure that exists in the vesicles. This mechanism may take place either at complete fusion of a vesicle with the presynaptic membrane or in the so-called kiss-and-run mode of neurotransmitter release. A simple hydrodynamic model of the viscous incompressible flow arising in the synaptic cleft is suggested. The occurrence of hydrodynamic flow (microjet) leads to more efficient transport of neurotransmitter than in the case of classical diffusive transport.

Original language	English (US)
Pages (from-to)	73-78
Number of pages	6
Journal	European Biophysics Journal
Volume	41
Issue number	1
DOIs	https://doi.org/10.1007/s00249-011-0759-3
State	Published - Jan 2012

All Science Journal Classification (ASJC) codes

Biophysics

Keywords

Chemical synapse
Exocytosis

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10.1007/s00249-011-0759-3

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AU - Skorinkin, A. I.

AU - Kovyazina, I. V.

AU - Nikolsky, E. E.

PY - 2012/1

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AB - It is shown that exocytosis in a chemical synapse may be accompanied by "microjet" formation due to the overpressure that exists in the vesicles. This mechanism may take place either at complete fusion of a vesicle with the presynaptic membrane or in the so-called kiss-and-run mode of neurotransmitter release. A simple hydrodynamic model of the viscous incompressible flow arising in the synaptic cleft is suggested. The occurrence of hydrodynamic flow (microjet) leads to more efficient transport of neurotransmitter than in the case of classical diffusive transport.

KW - Chemical synapse

KW - Exocytosis

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Hydrodynamic flow in a synaptic cleft during exocytosis

Abstract

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