Human cytomegalovirus UL69 protein induces cells to accumulate in G1 phase of the cell cycle

L. U. Mansuo, Thomas Shenk

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


Earlier studies have revealed that human cytomegalovirus rapidly inhibits the growth of fibroblasts, blocking cell cycle progression at multiple points, including the G1-to-S-phase transition. The present study demonstrates that the UL69 protein, a virus-encoded constituent of the virion, is able to arrest cell cycle progression when introduced into uninfected cells. Expression of the UL69 protein causes U2 OS cells and primary human fibroblasts to accumulate within the G1 compartment of the cell cycle, and serum fails to induce the progression of quiescent human fibroblasts into the S phase when the protein is present. Therefore, the UL69 protein is at least partially responsible for the cell cycle block that is instituted after infection of permissive cells with human cytomegalovirus.

Original languageEnglish (US)
Pages (from-to)676-683
Number of pages8
JournalJournal of virology
Issue number1
StatePublished - 1999

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology


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