Human cytomegalovirus infection inhibits cell cycle progression at multiple points, including the transition from G1 to S

Mansuo Lu, Thomas Shenk

Research output: Contribution to journalArticle

143 Scopus citations

Abstract

Human cytomegalovirus inhibits the growth of human foreskin fibroblast cells by 12 h after infection. Analysis of the cellular DNA content of infected cells by flow cytometry demonstrated thai cytomegalovirus does not arrest cell cycle progression at a single point. At least two blockages occur, one of which is in the G1 phase of the cell cycle. The G1 arrest introduced by cytomegalovirus infection blocks S-phase entry after serum stimulation.

Original languageEnglish (US)
Pages (from-to)8850-8857
Number of pages8
JournalJournal of virology
Volume70
Issue number12
DOIs
StatePublished - Dec 1996

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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