Human cytomegalovirus IE1 and IE2 proteins block apoptosis

Hua Zhu, Yuqiao Shen, Thomas Shenk

Research output: Contribution to journalArticlepeer-review

394 Scopus citations


Human cytomegalovirus-infected fibroblasts are resistant to the induction of apoptosis by superinfection with a mutant adenovirus unable to produce the viral E1B 19-kDa protein that normally causes an E1A protein-mediated apoptotic response. Two cytomegalovirus gene products that block apoptosis were identified. The IE1 and IE2 proteins each inhibit the induction of apoptosis by tumor necrosis factor α or by the E1B 19-kDa-protein-deficient adenovirus but not by irradiation with UV light. Our results suggest a new physiological role for the IE1 and IE2 proteins in the human cytomegalovirus replication cycle.

Original languageEnglish (US)
Pages (from-to)7960-7970
Number of pages11
JournalJournal of virology
Issue number12
StatePublished - Dec 1995

All Science Journal Classification (ASJC) codes

  • Insect Science
  • Virology
  • Microbiology
  • Immunology


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