Human cytomegalovirus: Coordinating cellular stress, signaling, and metabolic pathways

Thomas Shenk, James C. Alwine

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Viruses face a multitude of challenges when they infect a host cell. Cells have evolved innate defenses to protect against pathogens, and an infecting virus may induce a stress response that antagonizes viral replication. Further, the metabolic, oxidative, and cell cycle state may not be conducive to the viral infection. But viruses are fabulous manipulators, inducing host cells to use their own characteristic mechanisms and pathways to provide what the virus needs. This article centers on the manipulation of host cell metabolism by human cytomegalovirus (HCMV). We review the features of the metabolic program instituted by the virus, discuss the mechanisms underlying these dramatic metabolic changes, and consider how the altered program creates a synthetic milieu that favors efficient HCMV replication and spread.

Original languageEnglish (US)
Pages (from-to)355-374
Number of pages20
JournalAnnual review of virology
Issue number1
StatePublished - Sep 29 2014

All Science Journal Classification (ASJC) codes

  • Virology


  • AMPK
  • Glutaminolysis
  • Glycolysis
  • Host-virus interactions
  • MTOR
  • Unfolded protein response


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