Human Adult Neurogenesis: Evidence and Remaining Questions

Gerd Kempermann, Fred H. Gage, Ludwig Aigner, Hongjun Song, Maurice A. Curtis, Sandrine Thuret, H. Georg Kuhn, Sebastian Jessberger, Paul W. Frankland, Heather A. Cameron, Elizabeth Gould, Rene Hen, D. Nora Abrous, Nicolas Toni, Alejandro F. Schinder, Xinyu Zhao, Paul J. Lucassen, Jonas Frisén

Research output: Contribution to journalReview article

203 Scopus citations

Abstract

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

Original languageEnglish (US)
Pages (from-to)25-30
Number of pages6
JournalCell stem cell
Volume23
Issue number1
DOIs
StatePublished - Jul 5 2018

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Genetics
  • Cell Biology

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  • Cite this

    Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Gould, E., Hen, R., Abrous, D. N., Toni, N., Schinder, A. F., Zhao, X., Lucassen, P. J., & Frisén, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell stem cell, 23(1), 25-30. https://doi.org/10.1016/j.stem.2018.04.004