Human Adult Neurogenesis: Evidence and Remaining Questions

Gerd Kempermann; Fred H. Gage; Ludwig Aigner; Hongjun Song; Maurice A. Curtis; Sandrine Thuret; H. Georg Kuhn; Sebastian Jessberger; Paul W. Frankland; Heather A. Cameron; Elizabeth Gould; Rene Hen; D. Nora Abrous; Nicolas Toni; Alejandro F. Schinder; Xinyu Zhao; Paul J. Lucassen; Jonas Frisén

doi:10.1016/j.stem.2018.04.004

Human Adult Neurogenesis: Evidence and Remaining Questions

Gerd Kempermann, Fred H. Gage, Ludwig Aigner, Hongjun Song, Maurice A. Curtis, Sandrine Thuret, H. Georg Kuhn, Sebastian Jessberger, Paul W. Frankland, Heather A. Cameron, Elizabeth Gould, Rene Hen, D. Nora Abrous, Nicolas Toni, Alejandro F. Schinder, Xinyu Zhao, Paul J. Lucassen, Jonas Frisén

Research output: Contribution to journal › Review article › peer-review

572 Scopus citations

Abstract

Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

Original language	English (US)
Pages (from-to)	25-30
Number of pages	6
Journal	Cell stem cell
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/j.stem.2018.04.004
State	Published - Jul 5 2018

All Science Journal Classification (ASJC) codes

Genetics
Molecular Medicine
Cell Biology

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10.1016/j.stem.2018.04.004

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Kempermann, G., Gage, F. H., Aigner, L., Song, H., Curtis, M. A., Thuret, S., Kuhn, H. G., Jessberger, S., Frankland, P. W., Cameron, H. A., Gould, E., Hen, R., Abrous, D. N., Toni, N., Schinder, A. F., Zhao, X., Lucassen, P. J., & Frisén, J. (2018). Human Adult Neurogenesis: Evidence and Remaining Questions. Cell stem cell, 23(1), 25-30. https://doi.org/10.1016/j.stem.2018.04.004

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abstract = "Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.",

author = "Gerd Kempermann and Gage, {Fred H.} and Ludwig Aigner and Hongjun Song and Curtis, {Maurice A.} and Sandrine Thuret and Kuhn, {H. Georg} and Sebastian Jessberger and Frankland, {Paul W.} and Cameron, {Heather A.} and Elizabeth Gould and Rene Hen and Abrous, {D. Nora} and Nicolas Toni and Schinder, {Alejandro F.} and Xinyu Zhao and Lucassen, {Paul J.} and Jonas Fris{\'e}n",

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AU - Kempermann, Gerd

AU - Gage, Fred H.

AU - Aigner, Ludwig

AU - Song, Hongjun

AU - Curtis, Maurice A.

AU - Thuret, Sandrine

AU - Kuhn, H. Georg

AU - Jessberger, Sebastian

AU - Frankland, Paul W.

AU - Cameron, Heather A.

AU - Gould, Elizabeth

AU - Hen, Rene

AU - Abrous, D. Nora

AU - Toni, Nicolas

AU - Schinder, Alejandro F.

AU - Zhao, Xinyu

AU - Lucassen, Paul J.

AU - Frisén, Jonas

PY - 2018/7/5

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AB - Renewed discussion about whether or not adult neurogenesis exists in the human hippocampus, and the nature and strength of the supporting evidence, has been reignited by two prominently published reports with opposite conclusions. Here, we summarize the state of the field and argue that there is currently no reason to abandon the idea that adult-generated neurons make important functional contributions to neural plasticity and cognition across the human lifespan.

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Human Adult Neurogenesis: Evidence and Remaining Questions

Abstract

All Science Journal Classification (ASJC) codes

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