How to tie a peptide knot

Si Jia Pan, Wai Ling Cheung, Siyan Zhang, Mikhail Maksimov, A. James Link

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Lasso peptides are unique ribosomally-synthesized natural products with extraordinary stability. The focus of the present studies was on the role of the leader peptide in the biosynthesis of lasso peptides in bacteria as well as efforts to engineer the lasso peptide scaffold for new purposes.

Original languageEnglish (US)
Title of host publicationDevelopments in Biotechnology and Bioprocessing
PublisherAmerican Chemical Society
Pages113-127
Number of pages15
ISBN (Print)9780841229105
DOIs
StatePublished - Mar 8 2013

Publication series

NameACS Symposium Series
Volume1125
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Keywords

  • Antimicrobial activity
  • Lasso peptide
  • Lasso peptide libraries
  • Microcin J25
  • Peptide knot

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