How the Dorsal gradient works: Insights from postgenome technologies

Joung Woo Hong, David A. Hendrix, Dmitri Papatsenko, Michael S. Levine

Research output: Contribution to journalReview article

87 Scopus citations

Abstract

Gradients of extracellular signaling molecules and transcription factors are used in a variety of developmental processes, including the patterning of the Drosophila embryo, the establishment of diverse neuronal cell types in the vertebrate neural tube, and the anterior-posterior patterning of vertebrate limbs. Here, we discuss how a gradient of the maternal transcription factor Dorsal produces complex patterns of gene expression across the dorsal-ventral (DV) axis of the early Drosophila embryo. The identification of 60-70 Dorsal target genes, along with the characterization of ≈35 associated regulatory DNAs, suggests that there are at least six different regulatory codes driving diverse DV expression profiles.

Original languageEnglish (US)
Pages (from-to)20072-20076
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume105
Issue number51
DOIs
StatePublished - Dec 23 2008
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Drosophila
  • Embryo
  • Morphogen
  • Regulatory code

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