How long does it take to establish a morphogen gradient?

Alexander M. Berezhkovskii, Christine Sample, Stanislav Y. Shvartsman

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

A morphogen gradient is defined as a concentration field of a molecule that acts as a dose-dependent regulator of cell differentiation. One of the key questions in studies of morphogen gradients is whether they reach steady states on timescales relevant for developmental patterning. We propose a systematic approach for addressing this question and illustrate it by analyzing several models that account for diffusion and degradation of locally produced chemical signals.

Original languageEnglish (US)
Pages (from-to)L59-L61
JournalBiophysical Journal
Volume99
Issue number8
DOIs
StatePublished - Oct 20 2010

All Science Journal Classification (ASJC) codes

  • Biophysics

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