How important is EMT for cancer metastasis?

Toni Celià-Terrassa, Yibin Kang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

AEUpit:hPellieaal-steoc-omnefisrmenthcahtaylmlhaelatdrainngsleitvioenlsa(EreMreTp)r,easebnitoeldocgoicrraelcptlhye: nomenon of cellular plasticity initially reported in embryonic development, has been increasingly recognized for its importance in cancer progression and metastasis. Despite tremendous progress being made in the past 2 decades in our understanding of the molecular mechanism and functional importance of EMT in cancer, there are several mysteries around EMT that remain unresolved. In this Unsolved Mystery, we focus on the variety of EMT types in metastasis, cooperative and collective EMT behaviors, spatiotemporal characterization of EMT, and strategies of therapeutically targeting EMT. We also highlight new technical advances that will facilitate the efforts to elucidate the unsolved mysteries of EMT in metastasis.

Original languageEnglish (US)
Article numbere3002487
JournalPLoS biology
Volume22
Issue number2 February
DOIs
StatePublished - Feb 2024

All Science Journal Classification (ASJC) codes

  • General Neuroscience
  • General Biochemistry, Genetics and Molecular Biology
  • General Immunology and Microbiology
  • General Agricultural and Biological Sciences

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