How does the end begin?. Formation and maintenance of telomeres in ciliates and yeast

Virginia A. Zakian; Kurt Runge; Sy Shi Wang

doi:10.1016/0168-9525(90)90043-6

How does the end begin?. Formation and maintenance of telomeres in ciliates and yeast

Virginia A. Zakian, Kurt Runge, Sy Shi Wang

Molecular Biology

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Current models of telomere formation and replication involve either telomerase, a novel ribonucleoprotein, or recombination between the ends of DNA molecules. However, present models will have to be modified to explain recent data on telomere formation in yeast. An understanding of the mechanisms of telomere maintenance in yeast may reveal how other organisms with heterogeneous telomeric repeats replicate their chromosomal termini.

Original language	English (US)
Pages (from-to)	12-16
Number of pages	5
Journal	Trends in Genetics
Volume	6
Issue number	C
DOIs	https://doi.org/10.1016/0168-9525(90)90043-6
State	Published - 1990

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/0168-9525(90)90043-6

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title = "How does the end begin?. Formation and maintenance of telomeres in ciliates and yeast",

abstract = "Current models of telomere formation and replication involve either telomerase, a novel ribonucleoprotein, or recombination between the ends of DNA molecules. However, present models will have to be modified to explain recent data on telomere formation in yeast. An understanding of the mechanisms of telomere maintenance in yeast may reveal how other organisms with heterogeneous telomeric repeats replicate their chromosomal termini.",

author = "Zakian, {Virginia A.} and Kurt Runge and Wang, {Sy Shi}",

note = "Funding Information: Work in our lab is supported by grant GM-26938 from the NIH and grant NP-574 from the American Cancer Society. S-S.W. is supported by a fellowship from the Joan Taylor Guild. We thank M. Conrad, L. Sandell, R. Wellinger and J. Wright for their contributions to the ideas discussed in this paper.",

year = "1990",

doi = "10.1016/0168-9525(90)90043-6",

language = "English (US)",

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T1 - How does the end begin?. Formation and maintenance of telomeres in ciliates and yeast

AU - Zakian, Virginia A.

AU - Runge, Kurt

AU - Wang, Sy Shi

N1 - Funding Information: Work in our lab is supported by grant GM-26938 from the NIH and grant NP-574 from the American Cancer Society. S-S.W. is supported by a fellowship from the Joan Taylor Guild. We thank M. Conrad, L. Sandell, R. Wellinger and J. Wright for their contributions to the ideas discussed in this paper.

PY - 1990

Y1 - 1990

N2 - Current models of telomere formation and replication involve either telomerase, a novel ribonucleoprotein, or recombination between the ends of DNA molecules. However, present models will have to be modified to explain recent data on telomere formation in yeast. An understanding of the mechanisms of telomere maintenance in yeast may reveal how other organisms with heterogeneous telomeric repeats replicate their chromosomal termini.

AB - Current models of telomere formation and replication involve either telomerase, a novel ribonucleoprotein, or recombination between the ends of DNA molecules. However, present models will have to be modified to explain recent data on telomere formation in yeast. An understanding of the mechanisms of telomere maintenance in yeast may reveal how other organisms with heterogeneous telomeric repeats replicate their chromosomal termini.

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U2 - 10.1016/0168-9525(90)90043-6

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JO - Trends in Genetics

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IS - C

ER -

How does the end begin?. Formation and maintenance of telomeres in ciliates and yeast

Abstract

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