How Are Biomarkers Related to Physical and Mental Well-Being?

Christopher L. Seplaki, Noreen Goldman, Maxine Weinstein, Yu Hsuan Lin

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


We investigate how biological markers of individual responses to stressful experiences are associated with profiles of physical and mental functioning in a national sample of middle-aged and elderly Taiwanese. Data come from a population-based sample of middle-aged and elderly Taiwanese in 2000. The data combine rich biological measures with self-reported information on physical and mental health. Grade of membership methods are used to summarize functional status, and multinomial logit models provide information on the association between biological measures and function. The analysis identifies significant associations between biomarkers of stressful experience and profiles of physical and mental functioning. The estimates reveal the potential importance for health of both low and high values of biological parameters. The findings point to directions for future research regarding development of aggregate measures of cumulative dysregulation across multiple physiological systems.

Original languageEnglish (US)
Pages (from-to)201-217
Number of pages17
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Issue number3
StatePublished - Mar 2004

All Science Journal Classification (ASJC) codes

  • Geriatrics and Gerontology
  • Aging


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