HOT DNAs: A novel class of developmental enhancers

Emma Farley, Michael Levine

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.

Original languageEnglish (US)
Pages (from-to)873-876
Number of pages4
JournalGenes and Development
Issue number9
StatePublished - 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Genetics
  • Developmental Biology


  • Drosophila embryo development
  • Enhancer/cis-regulatory element
  • HOT region
  • Transcription factor


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