HOT DNAs: A novel class of developmental enhancers

Emma Farley; Michael Levine

doi:10.1101/gad.192583.112

HOT DNAs: A novel class of developmental enhancers

Emma Farley, Michael Levine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.

Original language	English (US)
Pages (from-to)	873-876
Number of pages	4
Journal	Genes and Development
Volume	26
Issue number	9
DOIs	https://doi.org/10.1101/gad.192583.112
State	Published - 2012
Externally published	Yes

All Science Journal Classification (ASJC) codes

Genetics
Developmental Biology

Keywords

Drosophila embryo development
Enhancer/cis-regulatory element
HOT region
Transcription factor

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10.1101/gad.192583.112

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AU - Levine, Michael

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AB - Enhancers mediate localized patterns of gene expression during development. A common feature of "traditional" enhancers is the presence of clustered binding motifs for sequence-specific transcription factors (TFs). In this issue of Genes & Development, Kvon and colleagues (pp. 908-913) present new evidence that HOT (highly occupied transcription) DNAs direct specific patterns of gene expression, despite being depleted for TF-binding motifs.

KW - Drosophila embryo development

KW - Enhancer/cis-regulatory element

KW - HOT region

KW - Transcription factor

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HOT DNAs: A novel class of developmental enhancers

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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