Host phylogeny and functional traits differentiate gut microbiomes in a diverse natural community of small mammals

Bianca R.P. Brown, Jacob R. Goheen, Seth D. Newsome, Robert M. Pringle, Todd M. Palmer, Leo M. Khasoha, Tyler R. Kartzinel

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

Differences in the bacterial communities inhabiting mammalian gut microbiomes tend to reflect the phylogenetic relatedness of their hosts, a pattern dubbed phylosymbiosis. Although most research on this pattern has compared the gut microbiomes of host species across biomes, understanding the evolutionary and ecological processes that generate phylosymbiosis requires comparisons across phylogenetic scales and under similar ecological conditions. We analysed the gut microbiomes of 14 sympatric small mammal species in a semi-arid African savanna, hypothesizing that there would be a strong phylosymbiotic pattern associated with differences in their body sizes and diets. Consistent with phylosymbiosis, microbiome dissimilarity increased with phylogenetic distance among hosts, ranging from congeneric sets of mice and hares that did not differ significantly in microbiome composition to species from different taxonomic orders that had almost no gut bacteria in common. While phylosymbiosis was detected among just the 11 species of rodents, it was substantially weaker at this scale than in comparisons involving all 14 species together. In contrast, microbiome diversity and composition were generally more strongly correlated with body size, dietary breadth, and dietary overlap in comparisons restricted to rodents than in those including all lineages. The starkest divides in microbiome composition thus reflected the broad evolutionary divergence of hosts, regardless of body size or diet, while subtler microbiome differences reflected variation in ecologically important traits of closely related hosts. Strong phylosymbiotic patterns arose deep in the phylogeny, and ecological filters that promote functional differentiation of cooccurring host species may disrupt or obscure this pattern near the tips.

Original languageEnglish (US)
Pages (from-to)2320-2334
Number of pages15
JournalMolecular ecology
Volume32
Issue number9
DOIs
StatePublished - May 2023

All Science Journal Classification (ASJC) codes

  • Genetics
  • Ecology, Evolution, Behavior and Systematics

Keywords

  • 16S rRNA
  • community ecology
  • phylogenetic scale
  • stable isotopes
  • symbiosis

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