Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs

Dhriti Tandon; Kyra Ressler; Daniel Petticord; Andrea Papa; Juliana Jiranek; Riley Wilkinson; Rebecca Y. Kartzinel; Elaine A. Ostrander; Nathaniel Burney; Carol Borden; Monique A.R. Udell; Bridgett Marie vonHoldt

doi:10.3390/genes10060439

Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs

Dhriti Tandon, Kyra Ressler, Daniel Petticord, Andrea Papa, Juliana Jiranek, Riley Wilkinson, Rebecca Y. Kartzinel, Elaine A. Ostrander, Nathaniel Burney, Carol Borden, Monique A.R. Udell, Bridgett Marie vonHoldt

Research output: Contribution to journal › Article › peer-review

9 Scopus citations

Abstract

Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability.

Original language	English (US)
Article number	439
Journal	Genes
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/genes10060439
State	Published - Jun 2019

All Science Journal Classification (ASJC) codes

Genetics(clinical)
Genetics

Keywords

Canis
Domestication
Genetics
Hypersociability
Transposons

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10.3390/genes10060439

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Tandon, D., Ressler, K., Petticord, D., Papa, A., Jiranek, J., Wilkinson, R., Kartzinel, R. Y., Ostrander, E. A., Burney, N., Borden, C., Udell, M. A. R., & vonHoldt, B. M. (2019). Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs. Genes, 10(6), Article 439. https://doi.org/10.3390/genes10060439

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title = "Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs",

abstract = "Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability.",

keywords = "Canis, Domestication, Genetics, Hypersociability, Transposons",

author = "Dhriti Tandon and Kyra Ressler and Daniel Petticord and Andrea Papa and Juliana Jiranek and Riley Wilkinson and Kartzinel, {Rebecca Y.} and Ostrander, {Elaine A.} and Nathaniel Burney and Carol Borden and Udell, {Monique A.R.} and vonHoldt, {Bridgett Marie}",

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year = "2019",

month = jun,

doi = "10.3390/genes10060439",

language = "English (US)",

volume = "10",

journal = "Genes",

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AU - Tandon, Dhriti

AU - Ressler, Kyra

AU - Petticord, Daniel

AU - Papa, Andrea

AU - Jiranek, Juliana

AU - Wilkinson, Riley

AU - Kartzinel, Rebecca Y.

AU - Ostrander, Elaine A.

AU - Burney, Nathaniel

AU - Borden, Carol

AU - Udell, Monique A.R.

AU - vonHoldt, Bridgett Marie

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N2 - Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability.

AB - Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability.

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KW - Domestication

KW - Genetics

KW - Hypersociability

KW - Transposons

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Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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