Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs

Dhriti Tandon; Kyra Ressler; Daniel Petticord; Andrea Papa; Juliana Jiranek; Riley Wilkinson; Rebecca Y. Kartzinel; Elaine A. Ostrander; Nathaniel Burney; Carol Borden; Monique A.R. Udell; Bridgett Marie vonHoldt

doi:10.3390/genes10060439

Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs

Dhriti Tandon, Kyra Ressler, Daniel Petticord, Andrea Papa, Juliana Jiranek, Riley Wilkinson, Rebecca Y. Kartzinel, Elaine A. Ostrander, Nathaniel Burney, Carol Borden, Monique A.R. Udell, Bridgett Marie vonHoldt

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability. Using our dataset of 837 dogs, 228 of which had paired survey-based behavioral data, we discovered that one of the insertions in WBSCR17 is the most important predictor of dog sociable behaviors related to human proximity, measured by the Canine Behavioral Assessment Research Questionnaire (C-BARQ

Original language	English (US)
Article number	439
Journal	Genes
Volume	10
Issue number	6
DOIs	https://doi.org/10.3390/genes10060439
State	Published - Jun 2019

All Science Journal Classification (ASJC) codes

Genetics
Genetics(clinical)

Keywords

Canis
Domestication
Genetics
Hypersociability
Transposons

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10.3390/genes10060439

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Tandon, Dhriti ; Ressler, Kyra ; Petticord, Daniel ; Papa, Andrea ; Jiranek, Juliana ; Wilkinson, Riley ; Kartzinel, Rebecca Y. ; Ostrander, Elaine A. ; Burney, Nathaniel ; Borden, Carol ; Udell, Monique A.R. ; vonHoldt, Bridgett Marie. / Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs. In: Genes. 2019 ; Vol. 10, No. 6.

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title = "Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs",

abstract = "Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability. Using our dataset of 837 dogs, 228 of which had paired survey-based behavioral data, we discovered that one of the insertions in WBSCR17 is the most important predictor of dog sociable behaviors related to human proximity, measured by the Canine Behavioral Assessment Research Questionnaire (C-BARQ",

keywords = "Canis, Domestication, Genetics, Hypersociability, Transposons",

author = "Dhriti Tandon and Kyra Ressler and Daniel Petticord and Andrea Papa and Juliana Jiranek and Riley Wilkinson and Kartzinel, {Rebecca Y.} and Ostrander, {Elaine A.} and Nathaniel Burney and Carol Borden and Udell, {Monique A.R.} and vonHoldt, {Bridgett Marie}",

note = "Funding Information: Funding: E.A.O. was funded by the Intramural Program of the National Human Genome Research Institute. This research was partially funded by the Princeton Department of Ecology & Evolutionary Biology{\textquoteright}s Porter {\textquoteright}52 Research Fund and the Princeton Office of Undergraduate Research. Publisher Copyright: {\textcopyright} 2019 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2019",

month = jun,

doi = "10.3390/genes10060439",

language = "English (US)",

volume = "10",

journal = "Genes",

issn = "2073-4425",

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Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs. / Tandon, Dhriti; Ressler, Kyra; Petticord, Daniel; Papa, Andrea; Jiranek, Juliana; Wilkinson, Riley; Kartzinel, Rebecca Y.; Ostrander, Elaine A.; Burney, Nathaniel; Borden, Carol; Udell, Monique A.R.; vonHoldt, Bridgett Marie.

In: Genes, Vol. 10, No. 6, 439, 06.2019.

Research output: Contribution to journal › Article › peer-review

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AU - Tandon, Dhriti

AU - Ressler, Kyra

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AU - Jiranek, Juliana

AU - Wilkinson, Riley

AU - Kartzinel, Rebecca Y.

AU - Ostrander, Elaine A.

AU - Burney, Nathaniel

AU - Borden, Carol

AU - Udell, Monique A.R.

AU - vonHoldt, Bridgett Marie

N1 - Funding Information: Funding: E.A.O. was funded by the Intramural Program of the National Human Genome Research Institute. This research was partially funded by the Princeton Department of Ecology & Evolutionary Biology’s Porter ’52 Research Fund and the Princeton Office of Undergraduate Research. Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2019/6

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N2 - Assistance dog training programs can see as many as 60% of their trainees dismissed. Many training programs utilize behavioral assays prior to admittance to identify likely successful candidates, yet such assays can be insconsistent. Recently, four canine retrotransposon mobile element insertions (MEIs) in or near genes WBSCR17 (Cfa6.6 and Cfa6.7), GTF2I (Cfa6.66) and POM121 (Cfa6.83) were identified in domestic dogs and gray wolves. Variations in these MEIs were significantly associated with a heightened propensity to initiate prolonged social contact or hypersociability. Using our dataset of 837 dogs, 228 of which had paired survey-based behavioral data, we discovered that one of the insertions in WBSCR17 is the most important predictor of dog sociable behaviors related to human proximity, measured by the Canine Behavioral Assessment Research Questionnaire (C-BARQ

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Homozygosity for mobile element insertions associated with WBSCR17 could predict success in assistance dog training programs

Abstract

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