Homeo box genes of the Antennapedia and Bithorax Complexes of Drosophila

Michael Regulski; Katherine Harding; Richard Kostriken; Francois Karch; Michael Levine; William McGinnis

doi:10.1016/0092-8674(85)90013-3

Homeo box genes of the Antennapedia and Bithorax Complexes of Drosophila

Michael Regulski, Katherine Harding, Richard Kostriken, Francois Karch, Michael Levine, William McGinnis

Research output: Contribution to journal › Article › peer-review

123 Scopus citations

Abstract

The Antennapedia, Ultrabithorax, and fushi tarazu genes of Drosophila melanogaster each contain a very similar protein coding sequence, the homeo box. Previously cloned homeo box sequences were used to isolate additional well conserved members of the homeo box gene family. The most strongly conserved members of the homeo box gene family map within either the Antennapedia or Bithorax gene complexes. The tissue distribution of transcripts encoded by the two rightmost homeo box genes of the Bithorax complex are compared with the iab-2 and iab-7 phenotypes.

Original language	English (US)
Pages (from-to)	71-80
Number of pages	10
Journal	Cell
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/0092-8674(85)90013-3
State	Published - Nov 1985
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Biochemistry, Genetics and Molecular Biology

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10.1016/0092-8674(85)90013-3

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title = "Homeo box genes of the Antennapedia and Bithorax Complexes of Drosophila",

abstract = "The Antennapedia, Ultrabithorax, and fushi tarazu genes of Drosophila melanogaster each contain a very similar protein coding sequence, the homeo box. Previously cloned homeo box sequences were used to isolate additional well conserved members of the homeo box gene family. The most strongly conserved members of the homeo box gene family map within either the Antennapedia or Bithorax gene complexes. The tissue distribution of transcripts encoded by the two rightmost homeo box genes of the Bithorax complex are compared with the iab-2 and iab-7 phenotypes.",

author = "Michael Regulski and Katherine Harding and Richard Kostriken and Francois Karch and Michael Levine and William McGinnis",

note = "Funding Information: We thank N. McGinnis for experimental and clerical assistance. We are also indebted to A. Kuroiwa, E. Hafen, and W. Gehring for communicating unpublished results, as well as for much assistance in the development of these experiments. Welcome Bender provided useful criticism of the manuscript, generously allowed us BX-C DNA, and freely shared unpublished results and his knowledge of BX-C genetics. We also thank Mark Zoller for help with the jab-7sequence. This work was supported by funds from the Searle Scholar Program to W. M. and from the National Institutes of Health to M. L.",

year = "1985",

month = nov,

doi = "10.1016/0092-8674(85)90013-3",

language = "English (US)",

volume = "43",

pages = "71--80",

journal = "Cell",

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T1 - Homeo box genes of the Antennapedia and Bithorax Complexes of Drosophila

AU - Regulski, Michael

AU - Harding, Katherine

AU - Kostriken, Richard

AU - Karch, Francois

AU - Levine, Michael

AU - McGinnis, William

N1 - Funding Information: We thank N. McGinnis for experimental and clerical assistance. We are also indebted to A. Kuroiwa, E. Hafen, and W. Gehring for communicating unpublished results, as well as for much assistance in the development of these experiments. Welcome Bender provided useful criticism of the manuscript, generously allowed us BX-C DNA, and freely shared unpublished results and his knowledge of BX-C genetics. We also thank Mark Zoller for help with the jab-7sequence. This work was supported by funds from the Searle Scholar Program to W. M. and from the National Institutes of Health to M. L.

PY - 1985/11

Y1 - 1985/11

N2 - The Antennapedia, Ultrabithorax, and fushi tarazu genes of Drosophila melanogaster each contain a very similar protein coding sequence, the homeo box. Previously cloned homeo box sequences were used to isolate additional well conserved members of the homeo box gene family. The most strongly conserved members of the homeo box gene family map within either the Antennapedia or Bithorax gene complexes. The tissue distribution of transcripts encoded by the two rightmost homeo box genes of the Bithorax complex are compared with the iab-2 and iab-7 phenotypes.

AB - The Antennapedia, Ultrabithorax, and fushi tarazu genes of Drosophila melanogaster each contain a very similar protein coding sequence, the homeo box. Previously cloned homeo box sequences were used to isolate additional well conserved members of the homeo box gene family. The most strongly conserved members of the homeo box gene family map within either the Antennapedia or Bithorax gene complexes. The tissue distribution of transcripts encoded by the two rightmost homeo box genes of the Bithorax complex are compared with the iab-2 and iab-7 phenotypes.

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Homeo box genes of the Antennapedia and Bithorax Complexes of Drosophila

Abstract

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