Histones and histone synthesis in sea urchin development

Joan V. Ruderman, Paul R. Gross

Research output: Contribution to journalArticlepeer-review

104 Scopus citations


Histones are synthesized and become a part of the chromatin as early as the first cleavage in sea urchins. Reproducible changes in relative amounts of individual histone fractions synthesized are observed during development. A new and electrophoretically distinct very lysine rich fraction appears at hatching in Arbacia and in the early gastrula of Lytechinus. When RNA synthesis is blocked by actinomycin D, maternal mRNA alone can direct a quantitatively and qualitatively changing pattern of histone synthesis as cleavage proceeds. Inhibition of DNA synthesis by hydroxyurea reduces synthesis of histones; the arginine-rich histones are more severely affected than the lysine-rich ones.

Original languageEnglish (US)
Pages (from-to)286-298
Number of pages13
JournalDevelopmental biology
Issue number2
StatePublished - Feb 1974
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology
  • Developmental Biology


Dive into the research topics of 'Histones and histone synthesis in sea urchin development'. Together they form a unique fingerprint.

Cite this