Histone H1.2 as a trigger for apoptosis

Nieng Yan, Yigong Shi

Research output: Contribution to journalShort surveypeer-review

19 Scopus citations


In response to DNA double-strand breaks, histone H1.2 translocates from the nucleus into the cytoplasm, leading to the mitochondrial release of cytochrome c and subsequent apoptosis of the cell. The molecular underpinnings for these processes remain enigmatic.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalNature Structural Biology
Issue number12
StatePublished - Dec 2003

All Science Journal Classification (ASJC) codes

  • Genetics
  • Structural Biology
  • Biochemistry


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