Histone H1.2 as a trigger for apoptosis

Nieng Yan, Yigong Shi

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

In response to DNA double-strand breaks, histone H1.2 translocates from the nucleus into the cytoplasm, leading to the mitochondrial release of cytochrome c and subsequent apoptosis of the cell. The molecular underpinnings for these processes remain enigmatic.

Original languageEnglish (US)
Pages (from-to)983-985
Number of pages3
JournalNature Structural Biology
Volume10
Issue number12
DOIs
StatePublished - Dec 1 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Structural Biology
  • Genetics

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