Histone deacetylases in herpesvirus replication and virus-stimulated host defense

Amanda J. Guise, Hanna G. Budayeva, Benjamin A. Diner, Ileana M. Cristea

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations

Abstract

Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.

Original languageEnglish (US)
Pages (from-to)1607-1632
Number of pages26
JournalViruses
Volume5
Issue number7
DOIs
StatePublished - Jun 27 2013

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Virology

Keywords

  • Acetylation
  • Chemoproteomics
  • Hdac
  • Herpesvirus
  • Ifi16
  • Metabolomics
  • Nf-κb
  • P53
  • Proteomics

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