Histone deacetylases in herpesvirus replication and virus-stimulated host defense

Amanda J. Guise; Hanna G. Budayeva; Benjamin A. Diner; Ileana M. Cristea

doi:10.3390/v5071607

Histone deacetylases in herpesvirus replication and virus-stimulated host defense

Amanda J. Guise, Hanna G. Budayeva, Benjamin A. Diner, Ileana M. Cristea

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.

Original language	English (US)
Pages (from-to)	1607-1632
Number of pages	26
Journal	Viruses
Volume	5
Issue number	7
DOIs	https://doi.org/10.3390/v5071607
State	Published - Jun 27 2013

All Science Journal Classification (ASJC) codes

Infectious Diseases
Virology

Keywords

Acetylation
Chemoproteomics
Hdac
Herpesvirus
Ifi16
Metabolomics
Nf-κb
P53
Proteomics

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10.3390/v5071607

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abstract = "Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based {"}omic{"} technologies to infectious disease research, offering a systems biology view of infection.",

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AU - Guise, Amanda J.

AU - Budayeva, Hanna G.

AU - Diner, Benjamin A.

AU - Cristea, Ileana M.

PY - 2013/6/27

Y1 - 2013/6/27

N2 - Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.

AB - Emerging evidence highlights a critical role for protein acetylation during herpesvirus infection. As prominent modulators of protein acetylation, histone deacetylases (HDACs) are essential transcriptional and epigenetic regulators. Not surprisingly, viruses have evolved a wide array of mechanisms to subvert HDAC functions. Here, we review the mechanisms underlying HDAC regulation during herpesvirus infection. We next discuss the roles of acetylation in host defense against herpesvirus infection. Finally, we provide a perspective on the contribution of current mass spectrometry-based "omic" technologies to infectious disease research, offering a systems biology view of infection.

KW - Acetylation

KW - Chemoproteomics

KW - Hdac

KW - Herpesvirus

KW - Ifi16

KW - Metabolomics

KW - Nf-κb

KW - P53

KW - Proteomics

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DO - 10.3390/v5071607

M3 - Review article

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JO - Viruses

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Histone deacetylases in herpesvirus replication and virus-stimulated host defense

Abstract

All Science Journal Classification (ASJC) codes

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