TY - JOUR
T1 - Hippocampal structure predicts statistical learning and associative inference abilities during development
AU - Schlichting, Margaret L.
AU - Guarino, Katharine F.
AU - Schapiro, Anna C.
AU - Turk-Browne, Nicholas B.
AU - Preston, Alison R.
N1 - Funding Information:
The authors thank Jessica Church-Lang, Michael Mack, Tammy Tran, and Amelia Wattenberger for assistance with participant recruitment, data collection, and helpful discussions. This work was supported by the National Institutes of Health (grants R01MH100121 and R21HD083785 to A. R. P. and R01EY021755 to N. B. T.-B.), the National Science Foundation CAREER Award (grants 1056019 to A. R. P.), a University of Texas Research Grant to A. R. P., and the Department of Defense through the National Defense Science and Engineering Graduate Fellowship (NDSEG) Program (M. L. S.).
Publisher Copyright:
© 2016 Massachusetts Institute of Technology.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Despite the importance of learning and remembering across the lifespan, little is known about how the episodic memory system develops to support the extraction of associative structure from the environment. Here, we relate individual differences in volumes along the hippocampal long axis to performance on statistical learning and associative inference tasks—both of which require encoding associations that span multiple episodes—in a developmental sample ranging from ages 6 to 30 years. Relating age to volume, we found dissociable patterns across the hippocampal long axis, with opposite non-linear volume changes in the head and body. These structural differences were paralleled by performance gains across the age range on both tasks, suggesting improvements in the crossepisode binding ability from childhood to adulthood. Controlling for age, we also found that smaller hippocampal heads were associated with superior behavioral performance on both tasks, consistent with this region’s hypothesized role in forming generalized codes spanning events. Collectively, these results highlight the importance of examining hippocampal development as a function of position along the hippocampal axis and suggest that the hippocampal head is particularly important in encoding associative structure across development.
AB - Despite the importance of learning and remembering across the lifespan, little is known about how the episodic memory system develops to support the extraction of associative structure from the environment. Here, we relate individual differences in volumes along the hippocampal long axis to performance on statistical learning and associative inference tasks—both of which require encoding associations that span multiple episodes—in a developmental sample ranging from ages 6 to 30 years. Relating age to volume, we found dissociable patterns across the hippocampal long axis, with opposite non-linear volume changes in the head and body. These structural differences were paralleled by performance gains across the age range on both tasks, suggesting improvements in the crossepisode binding ability from childhood to adulthood. Controlling for age, we also found that smaller hippocampal heads were associated with superior behavioral performance on both tasks, consistent with this region’s hypothesized role in forming generalized codes spanning events. Collectively, these results highlight the importance of examining hippocampal development as a function of position along the hippocampal axis and suggest that the hippocampal head is particularly important in encoding associative structure across development.
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U2 - 10.1162/jocn_a_01028
DO - 10.1162/jocn_a_01028
M3 - Article
C2 - 27575916
AN - SCOPUS:85001044584
SN - 0898-929X
VL - 29
SP - 37
EP - 51
JO - Journal of cognitive neuroscience
JF - Journal of cognitive neuroscience
IS - 1
ER -