Hippocampal Contributions to Model-Based Planning and Spatial Memory

Oliver M. Vikbladh, Michael R. Meager, John King, Karen Blackmon, Orrin Devinsky, Daphna Shohamy, Neil Burgess, Nathaniel D. Daw

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Little is known about the neural mechanisms that allow humans and animals to plan actions using knowledge of task contingencies. Emerging theories hypothesize that it involves the same hippocampal mechanisms that support self-localization and memory for locations. Yet limited direct evidence supports the link between planning and the hippocampal place map. We addressed this by investigating model-based planning and place memory in healthy controls and epilepsy patients treated using unilateral anterior temporal lobectomy with hippocampal resection. Both functions were impaired in the patient group. Specifically, the planning impairment was related to right hippocampal lesion size, controlling for overall lesion size. Furthermore, although planning and boundary-driven place memory covaried in the control group, this relationship was attenuated in patients, consistent with both functions relying on the same structure in the healthy brain. These findings clarify both the neural mechanism of model-based planning and the scope of hippocampal contributions to behavior. Testing patients with hippocampal damage, Vikbladh et al. demonstrate that model-based planning and place memory rely on a common hippocampal substrate. The study bridges the reinforcement learning and spatial memory literatures to clarify the scope of hippocampal contributions to behavior.

Original languageEnglish (US)
Pages (from-to)683-693.e4
JournalNeuron
Volume102
Issue number3
DOIs
StatePublished - May 8 2019

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Keywords

  • anterior temporal lobe
  • decision-making
  • hippocampus
  • human
  • lesion
  • memory
  • model-based
  • planning
  • reinforcement learning
  • spatial

Fingerprint Dive into the research topics of 'Hippocampal Contributions to Model-Based Planning and Spatial Memory'. Together they form a unique fingerprint.

  • Cite this

    Vikbladh, O. M., Meager, M. R., King, J., Blackmon, K., Devinsky, O., Shohamy, D., Burgess, N., & Daw, N. D. (2019). Hippocampal Contributions to Model-Based Planning and Spatial Memory. Neuron, 102(3), 683-693.e4. https://doi.org/10.1016/j.neuron.2019.02.014