Highly potent, chemically stable quorum sensing agonists for vibrio Cholerae

Lark J. Perez, Theodora K. Karagounis, Amanda Hurley, Bonnie Lynn Bassler, Martin F. Semmelhack

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

In the Vibrio cholerae pathogen, initiation of bacterial quorum sensing pathways serves to suppress virulence. We describe herein a potent and chemically stable small molecule agonist of V. cholerae quorum sensing, which was identified through rational drug design based on the native quorum sensing signal. This novel agonist may serve as a useful lead compound for the control of virulence in V. cholerae.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalChemical Science
Volume5
Issue number1
DOIs
StatePublished - Jan 2014

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

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