Reaction of chiral amide enolate Li-1 with (S)-glycidyl tosylate 11 affords the epoxide 3 in 72% yield with high diastereoselectivity. Epoxide 3 is converted to the orally-active HIV-1 protease inhibitor L-735,524 in 71% isolated yield.
|Original language||English (US)|
|Number of pages||4|
|State||Published - 1994|
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry