High-yield activation of scaffold polymer surfaces to attach cell adhesion molecules

T. Joseph Dennes, Geoffrey C. Hunt, Jean E. Schwarzbauer, Jeffrey Schwartz

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Zirconium tetra(tert-butoxide) reacts with surface amide groups of polyamide nylon 6/6 to give (η2-amidate)zirconium complexes in high yield. These surface complexes react to bond the cell-adhesive peptide arginine-glycine-aspartic acid (RGD) to the polymer surface. A surface loading of 0.18 nmol/cm2 of RGD is achieved, which is 20-1000 times higher than previously reported attainable on natural or synthetic polymers by other strategies. Approximately 40% of the nylon surface is covered by the RGD, which gives a surface that is both stable to hydrolysis and highly active for cell adhesion and spreading in vitro.

Original languageEnglish (US)
Pages (from-to)93-97
Number of pages5
JournalJournal of the American Chemical Society
Volume129
Issue number1
DOIs
StatePublished - Jan 10 2007

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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