Abstract
Hydrodynamic forces due to the anisotropic shape of Drosophila embryo can rapidly orient it in an upright position. We used this effect and inertia hydrodynamics to design a microfluidics embryo trap array (META) that orders and vertically orients hundreds of embryos in a matter of minutes. Using META, we quantified morphogen gradients in the dorsoventral patterning system, a task that has been until now complicated by the need to manually orient individual embryos.
Original language | English (US) |
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Title of host publication | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
Pages | 1676-1678 |
Number of pages | 3 |
State | Published - Dec 1 2010 |
Event | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 - Groningen, Netherlands Duration: Oct 3 2010 → Oct 7 2010 |
Publication series
Name | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
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Volume | 3 |
Other
Other | 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2010, MicroTAS 2010 |
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Country/Territory | Netherlands |
City | Groningen |
Period | 10/3/10 → 10/7/10 |
All Science Journal Classification (ASJC) codes
- Control and Systems Engineering
Keywords
- Drosophila
- High-throughput
- Imaging
- Morphogen gradient
- Quantitative analysis
- Systems biology