High-speed microfluidic differential manometer for cellular-scale hydrodynamics

Manouk Abkarian, Magalie Faivre, Howard A. Stone

Research output: Contribution to journalArticlepeer-review

135 Scopus citations

Abstract

We propose a broadly applicable high-speed microfluidic approach for measuring dynamical pressure-drop variations along a micrometer-sized channel and illustrate the potential of the technique by presenting measurements of the additional pressure drop produced at the scale of individual flowing cells. The influence of drug-modified mechanical properties of the cell membrane is shown. Finally, single hemolysis events during flow are recorded simultaneously with the critical pressure drop for the rupture of the membrane. This scale-independent measurement approach can be applied to any dynamical process or event that changes the hydrodynamic resistance of micro- or nanochannels.

Original languageEnglish (US)
Pages (from-to)538-542
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume103
Issue number3
DOIs
StatePublished - Jan 17 2006
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • General

Keywords

  • Hemolysis
  • Membrane properties
  • Microcirculation
  • Pressure measurement
  • Red blood cell

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