High-frequency repetitive transcranial magnetic stimulation delays rapid eye movement sleep

Stefan Cohrs; Frithjof Tergau; Sebastian Riech; Sabine Kastner; Walter Paulus; Ulf Ziemann; Eckart Rüther; Göran Hajak

doi:10.1097/00001756-199810260-00019

High-frequency repetitive transcranial magnetic stimulation delays rapid eye movement sleep

Stefan Cohrs, Frithjof Tergau, Sebastian Riech, Sabine Kastner, Walter Paulus, Ulf Ziemann, Eckart Rüther, Göran Hajak

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Repetitive transcranial magnetic stimulation (rTMS) is a promising new treatment for patients with major depression. However, the mechanisms underlying the antidepressive action of rTMS are widely unclear. Rapid eye movement (REM) sleep has been shown to play an important role in the pathophysiology of depression. In the present study we demonstrate that rTMS delays the first REM sleep epoch on average by 17 min (102.6 ± 22.5 min vs 85.7 ± 18.8 min; p < 0.02) and prolongs the nonREM-REM cycle length (109.1 ± 11.4 min vs 101.8 ± 13.2 min, p < 0.012). These rTMS-induced changes in REM sleep variables correspond to findings observed after pharmacological and electroconvulsive treatment of depression. Therefore, it is likely that the capability of rTMS to affect circadian and ultradian biological rhythms contributes to its antidepressive action.

Original language	English (US)
Pages (from-to)	3439-3443
Number of pages	5
Journal	NeuroReport
Volume	9
Issue number	15
DOIs	https://doi.org/10.1097/00001756-199810260-00019
State	Published - Oct 26 1998
Externally published	Yes

All Science Journal Classification (ASJC) codes

General Neuroscience

Keywords

Depression
Polysomnography
REM sleep
Rapid eye movement sleep
Repetitive transcranial

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10.1097/00001756-199810260-00019

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title = "High-frequency repetitive transcranial magnetic stimulation delays rapid eye movement sleep",

abstract = "Repetitive transcranial magnetic stimulation (rTMS) is a promising new treatment for patients with major depression. However, the mechanisms underlying the antidepressive action of rTMS are widely unclear. Rapid eye movement (REM) sleep has been shown to play an important role in the pathophysiology of depression. In the present study we demonstrate that rTMS delays the first REM sleep epoch on average by 17 min (102.6 ± 22.5 min vs 85.7 ± 18.8 min; p < 0.02) and prolongs the nonREM-REM cycle length (109.1 ± 11.4 min vs 101.8 ± 13.2 min, p < 0.012). These rTMS-induced changes in REM sleep variables correspond to findings observed after pharmacological and electroconvulsive treatment of depression. Therefore, it is likely that the capability of rTMS to affect circadian and ultradian biological rhythms contributes to its antidepressive action.",

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AU - Cohrs, Stefan

AU - Tergau, Frithjof

AU - Riech, Sebastian

AU - Kastner, Sabine

AU - Paulus, Walter

AU - Ziemann, Ulf

AU - Rüther, Eckart

AU - Hajak, Göran

PY - 1998/10/26

Y1 - 1998/10/26

N2 - Repetitive transcranial magnetic stimulation (rTMS) is a promising new treatment for patients with major depression. However, the mechanisms underlying the antidepressive action of rTMS are widely unclear. Rapid eye movement (REM) sleep has been shown to play an important role in the pathophysiology of depression. In the present study we demonstrate that rTMS delays the first REM sleep epoch on average by 17 min (102.6 ± 22.5 min vs 85.7 ± 18.8 min; p < 0.02) and prolongs the nonREM-REM cycle length (109.1 ± 11.4 min vs 101.8 ± 13.2 min, p < 0.012). These rTMS-induced changes in REM sleep variables correspond to findings observed after pharmacological and electroconvulsive treatment of depression. Therefore, it is likely that the capability of rTMS to affect circadian and ultradian biological rhythms contributes to its antidepressive action.

AB - Repetitive transcranial magnetic stimulation (rTMS) is a promising new treatment for patients with major depression. However, the mechanisms underlying the antidepressive action of rTMS are widely unclear. Rapid eye movement (REM) sleep has been shown to play an important role in the pathophysiology of depression. In the present study we demonstrate that rTMS delays the first REM sleep epoch on average by 17 min (102.6 ± 22.5 min vs 85.7 ± 18.8 min; p < 0.02) and prolongs the nonREM-REM cycle length (109.1 ± 11.4 min vs 101.8 ± 13.2 min, p < 0.012). These rTMS-induced changes in REM sleep variables correspond to findings observed after pharmacological and electroconvulsive treatment of depression. Therefore, it is likely that the capability of rTMS to affect circadian and ultradian biological rhythms contributes to its antidepressive action.

KW - Depression

KW - Polysomnography

KW - REM sleep

KW - Rapid eye movement sleep

KW - Repetitive transcranial

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High-frequency repetitive transcranial magnetic stimulation delays rapid eye movement sleep

Abstract

All Science Journal Classification (ASJC) codes

Keywords

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