Heterogeneous bacterial persisters and engineering approaches to eliminate them

Kyle R. Allison; Mark P. Brynildsen; James J. Collins

doi:10.1016/j.mib.2011.09.002

Heterogeneous bacterial persisters and engineering approaches to eliminate them

Kyle R. Allison, Mark P. Brynildsen, James J. Collins

Research output: Contribution to journal › Review article › peer-review

160 Scopus citations

Abstract

Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.

Original language	English (US)
Pages (from-to)	593-598
Number of pages	6
Journal	Current opinion in microbiology
Volume	14
Issue number	5
DOIs	https://doi.org/10.1016/j.mib.2011.09.002
State	Published - Oct 2011
Externally published	Yes

All Science Journal Classification (ASJC) codes

Microbiology (medical)
Infectious Diseases
Microbiology

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10.1016/j.mib.2011.09.002

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title = "Heterogeneous bacterial persisters and engineering approaches to eliminate them",

abstract = "Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.",

author = "Allison, \{Kyle R.\} and Brynildsen, \{Mark P.\} and Collins, \{James J.\}",

note = "Funding Information: We thank Daniel J. Dwyer and D. Ewen Cameron for helpful suggestions on the manuscript. This work was supported by the NIH Director's Pioneer Award Program and the Howard Hughes Medical Institute . ",

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AU - Allison, Kyle R.

AU - Brynildsen, Mark P.

AU - Collins, James J.

N1 - Funding Information: We thank Daniel J. Dwyer and D. Ewen Cameron for helpful suggestions on the manuscript. This work was supported by the NIH Director's Pioneer Award Program and the Howard Hughes Medical Institute .

PY - 2011/10

Y1 - 2011/10

N2 - Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.

AB - Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.

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DO - 10.1016/j.mib.2011.09.002

M3 - Review article

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AN - SCOPUS:80053906154

SN - 1369-5274

VL - 14

SP - 593

EP - 598

JO - Current opinion in microbiology

JF - Current opinion in microbiology

IS - 5

ER -

Heterogeneous bacterial persisters and engineering approaches to eliminate them

Abstract

All Science Journal Classification (ASJC) codes

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