Heterogeneous bacterial persisters and engineering approaches to eliminate them

Kyle R. Allison, Mark P. Brynildsen, James J. Collins

Research output: Contribution to journalReview article

113 Scopus citations

Abstract

Bacterial persistence is a state in which a subpopulation of cells (persisters) survives antibiotic treatment, and has been implicated in the tolerance of clinical infections and the recalcitrance of biofilms. There has been a renewed interest in the role of bacterial persisters in treatment failure in light of a wealth of recent findings. Here we review recent laboratory studies of bacterial persistence. Further, we pose the hypothesis that each bacterial population may contain a diverse collection of persisters and discuss engineering strategies for persister eradication.

Original languageEnglish (US)
Pages (from-to)593-598
Number of pages6
JournalCurrent opinion in microbiology
Volume14
Issue number5
DOIs
StatePublished - Oct 2011

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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