TY - JOUR
T1 - Hepatocarcinogenesis associated with hepatitis B, delta and C viruses
AU - Shirvani-Dastgerdi, Elham
AU - Schwartz, Robert E.
AU - Ploss, Alexander
N1 - Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.
AB - Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.
UR - http://www.scopus.com/inward/record.url?scp=84982705840&partnerID=8YFLogxK
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U2 - 10.1016/j.coviro.2016.07.009
DO - 10.1016/j.coviro.2016.07.009
M3 - Review article
C2 - 27504999
AN - SCOPUS:84982705840
SN - 1879-6257
VL - 20
SP - 1
EP - 10
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -