Hepatocarcinogenesis associated with hepatitis B, delta and C viruses

Elham Shirvani-Dastgerdi, Robert E. Schwartz, Alexander Ploss

Research output: Contribution to journalReview article

26 Scopus citations

Abstract

Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalCurrent Opinion in Virology
Volume20
DOIs
StatePublished - Oct 1 2016

All Science Journal Classification (ASJC) codes

  • Virology

Fingerprint Dive into the research topics of 'Hepatocarcinogenesis associated with hepatitis B, delta and C viruses'. Together they form a unique fingerprint.

  • Cite this