TY - JOUR
T1 - Hepatocarcinogenesis associated with hepatitis B, delta and C viruses
AU - Shirvani-Dastgerdi, Elham
AU - Schwartz, Robert E.
AU - Ploss, Alexander
N1 - Funding Information:
The authors would like to thank members of the Ploss lab for critical discussions of the manuscript and in particular Jenna Gaska for editing. Work in the Ploss laboratory is in part supported by grants from the National Institutes of Health ( R01 AI079031 , R01 AI107301 , R21AI117213 ), a Research Scholar Award from the American Cancer Society ( RSG-15-048-01-MPC ), a Burroughs Wellcome Fund Award for Investigators in Pathogenesis and the Grand Challenge Program of Princeton University. RES is supported by grants from the National Institutes of Health ( R21AI117213 and 1K08DK101754 ), the Weill Cornell Center for Advanced Digestive Care , and the Alice Bohmfalk Charitable Trust . ESD is a recipient of a fellowship from the German Research Foundation (Deutsche Forschungsgemeinschaft). We apologize to all colleagues whose work could not be cited due to space constraints.
Publisher Copyright:
© 2016 Elsevier B.V.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.
AB - Globally, over half a billion people are persistently infected with hepatitis B (HBV) and/or hepatitis C viruses. Chronic HBV and HCV infection frequently lead to fibrosis, cirrhosis and hepatocellular carcinoma (HCC). Co-infections with hepatitis delta virus (HDV), a subviral satellite requiring HBV for its propagation, accelerates the progression of liver disease toward HCC. The mechanisms by which these viruses cause malignant transformation, culminating in HCC, remain incompletely understood, partially due to the lack of adequate experimental models for dissecting these complex disease processes in vivo.
UR - http://www.scopus.com/inward/record.url?scp=84982705840&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982705840&partnerID=8YFLogxK
U2 - 10.1016/j.coviro.2016.07.009
DO - 10.1016/j.coviro.2016.07.009
M3 - Review article
C2 - 27504999
AN - SCOPUS:84982705840
SN - 1879-6257
VL - 20
SP - 1
EP - 10
JO - Current Opinion in Virology
JF - Current Opinion in Virology
ER -