Hepatitis C virus host cell entry

Alexander Ploss, Matthew J. Evans

Research output: Contribution to journalReview article

63 Scopus citations

Abstract

The hepatitis C virus (HCV) is a major medical problem with at least 130 million infected individuals worldwide. Over the last decade multiple host factors required for HCV cell entry have been identified, but a detailed understanding of their mechanistic interplay remains elusive. Nonetheless, recent advances in defining species-specific barriers of HCV transmission have allowed the identification of a minimal set of entry factors that are required for HCV infection of rodent cells and has culminated in an animal model that recapitulates HCV entry in vivo. A detailed understanding of the viral uptake pathway is imperative to define new drug targets allowing for more effective intervention against this devastating disease.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
JournalCurrent Opinion in Virology
Volume2
Issue number1
DOIs
StatePublished - Feb 2012
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Virology

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