Helix-Coil Stability Constants for the Naturally Occurring Amino Acids in Water. 17. Threonine Parameters from Random Poly(hydroxybutylglutamine-co-L-threonine)

M. H. Hecht, B. O. Zweifel, H. A. Scheraga

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

The synthesis and characterization of water-soluble random copolymers containing L-threonine with N5-(4-hydroxybutyl)-L-glutamine and the thermally induced helix-coil transitions of these copolymers in water are described. The incorporation of L-threonine was found to decrease the helix content of the copolymers in water at all temperatures. The Zimm-Bragg parameters σ and s for the helix-coil transition of poly(L-threonine) in water were deduced from an analysis of the melting curves of the copolymers in the manner described in earlier papers. The computed values of s indicate that L-threonine destabilizes helical sequences at all temperatures in the range of 0-70.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalMacromolecules
Volume11
Issue number3
DOIs
StatePublished - Jan 1 1978
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Organic Chemistry
  • Polymers and Plastics
  • Inorganic Chemistry
  • Materials Chemistry

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