TY - JOUR
T1 - Hedgehog signaling in germ cell migration
AU - Deshpande, Girish
AU - Swanhart, Lisa
AU - Chiang, Phyllis
AU - Schedl, Paul
N1 - Funding Information:
We thank Ira Clark, Steve DiNardo, Dan Kalderon, Paul Lasko, Haifan Lin, Roel Nusse, Norbert Perrimon, Trudi Schupbach, Gary Struhl, and the Bloomington Stock Center for various fly stocks and antibodies. We are particularly grateful to Trudi Schupbach, Eric Wieschaus, and Shirley Tilghman for advice throughout the course of this work and comments on the manuscript. We would like to thank Joe Goodhouse for help with the confocal microscopy. Gordon Gray provided fly food. This work was supported by an NIH grant to P.S.
PY - 2001/9/21
Y1 - 2001/9/21
N2 - The primitive gonad of the Drosophila embryo is formed from two cell types, the somatic gonad precursor cells (SGPs) and the germ cells, which originate at distant sites. To reach the SGPs the germ cells must undergo a complex series of cell movements. While there is evidence that attractive and repulsive signals guide germ cell migration through the embryo, the molecular identity of these instructive molecules has remained elusive. Here, we present evidence suggesting that hedgehog (hh) may serve as such an attractive guidance cue. Misexpression of hh in the soma induces germ cells to migrate to inappropriate locations. Conversely, cell-autonomous components of the hh pathway appear to be required in the germline for proper germ cell migration.
AB - The primitive gonad of the Drosophila embryo is formed from two cell types, the somatic gonad precursor cells (SGPs) and the germ cells, which originate at distant sites. To reach the SGPs the germ cells must undergo a complex series of cell movements. While there is evidence that attractive and repulsive signals guide germ cell migration through the embryo, the molecular identity of these instructive molecules has remained elusive. Here, we present evidence suggesting that hedgehog (hh) may serve as such an attractive guidance cue. Misexpression of hh in the soma induces germ cells to migrate to inappropriate locations. Conversely, cell-autonomous components of the hh pathway appear to be required in the germline for proper germ cell migration.
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U2 - 10.1016/S0092-8674(01)00488-3
DO - 10.1016/S0092-8674(01)00488-3
M3 - Article
C2 - 11572781
AN - SCOPUS:0035929145
SN - 0092-8674
VL - 106
SP - 759
EP - 769
JO - Cell
JF - Cell
IS - 6
ER -