Hedgehog signaling in germ cell migration

Girish Deshpande, Lisa Swanhart, Phyllis Chiang, Paul Schedl

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


The primitive gonad of the Drosophila embryo is formed from two cell types, the somatic gonad precursor cells (SGPs) and the germ cells, which originate at distant sites. To reach the SGPs the germ cells must undergo a complex series of cell movements. While there is evidence that attractive and repulsive signals guide germ cell migration through the embryo, the molecular identity of these instructive molecules has remained elusive. Here, we present evidence suggesting that hedgehog (hh) may serve as such an attractive guidance cue. Misexpression of hh in the soma induces germ cells to migrate to inappropriate locations. Conversely, cell-autonomous components of the hh pathway appear to be required in the germline for proper germ cell migration.

Original languageEnglish (US)
Pages (from-to)759-769
Number of pages11
Issue number6
StatePublished - Sep 21 2001

All Science Journal Classification (ASJC) codes

  • General Biochemistry, Genetics and Molecular Biology


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