Abstract
Product-feedback inhibition is a ubiquitous regulatory scheme for maintaining homeostasis in living cells. Individual metabolic pathways with product-feedback inhibition are stable as long as one pathway step is rate limiting. However, pathways are often coupled both by the use of a common substrate and by stoichiometric utilization of their products for cell growth. We show that such a coupled network with product-feedback inhibition may exhibit limit-cycle oscillations which arise via a Hopf bifurcation. Our results highlight novel evolutionary constraints on the architecture of metabolism.
Original language | English (US) |
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Article number | 138105 |
Journal | Physical review letters |
Volume | 98 |
Issue number | 13 |
DOIs | |
State | Published - Mar 30 2007 |
All Science Journal Classification (ASJC) codes
- General Physics and Astronomy