Growth-induced instability in metabolic networks

Sidhartha Goyal, Ned S. Wingreen

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


Product-feedback inhibition is a ubiquitous regulatory scheme for maintaining homeostasis in living cells. Individual metabolic pathways with product-feedback inhibition are stable as long as one pathway step is rate limiting. However, pathways are often coupled both by the use of a common substrate and by stoichiometric utilization of their products for cell growth. We show that such a coupled network with product-feedback inhibition may exhibit limit-cycle oscillations which arise via a Hopf bifurcation. Our results highlight novel evolutionary constraints on the architecture of metabolism.

Original languageEnglish (US)
Article number138105
JournalPhysical review letters
Issue number13
StatePublished - Mar 30 2007

All Science Journal Classification (ASJC) codes

  • General Physics and Astronomy


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