TY - JOUR
T1 - Graphene-based wireless bacteria detection on tooth enamel
AU - Mannoor, Manu S.
AU - Tao, Hu
AU - Clayton, Jefferson D.
AU - Sengupta, Amartya
AU - Kaplan, David L.
AU - Naik, Rajesh R.
AU - Verma, Naveen
AU - Omenetto, Fiorenzo G.
AU - McAlpine, Michael C.
PY - 2012
Y1 - 2012
N2 - Direct interfacing of nanosensors onto biomaterials could impact health quality monitoring and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due to its nanoscale nature. Here we show that graphene can be printed onto water-soluble silk. This in turn permits intimate biotransfer of graphene nanosensors onto biomaterials, including tooth enamel. The result is a fully biointerfaced sensing platform, which can be tuned to detect target analytes. For example, via self-assembly of antimicrobial peptides onto graphene, we show bioselective detection of bacteria at single-cell levels. Incorporation of a resonant coil eliminates the need for onboard power and external connections. Combining these elements yields two-tiered interfacing of peptideĝ€"graphene nanosensors with biomaterials. In particular, we demonstrate integration onto a tooth for remote monitoring of respiration and bacteria detection in saliva. Overall, this strategy of interfacing graphene nanosensors with biomaterials represents a versatile approach for ubiquitous detection of biochemical targets.
AB - Direct interfacing of nanosensors onto biomaterials could impact health quality monitoring and adaptive threat detection. Graphene is capable of highly sensitive analyte detection due to its nanoscale nature. Here we show that graphene can be printed onto water-soluble silk. This in turn permits intimate biotransfer of graphene nanosensors onto biomaterials, including tooth enamel. The result is a fully biointerfaced sensing platform, which can be tuned to detect target analytes. For example, via self-assembly of antimicrobial peptides onto graphene, we show bioselective detection of bacteria at single-cell levels. Incorporation of a resonant coil eliminates the need for onboard power and external connections. Combining these elements yields two-tiered interfacing of peptideĝ€"graphene nanosensors with biomaterials. In particular, we demonstrate integration onto a tooth for remote monitoring of respiration and bacteria detection in saliva. Overall, this strategy of interfacing graphene nanosensors with biomaterials represents a versatile approach for ubiquitous detection of biochemical targets.
UR - http://www.scopus.com/inward/record.url?scp=84859198476&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859198476&partnerID=8YFLogxK
U2 - 10.1038/ncomms1767
DO - 10.1038/ncomms1767
M3 - Article
C2 - 22453836
AN - SCOPUS:84859198476
SN - 2041-1723
VL - 3
JO - Nature communications
JF - Nature communications
M1 - 763
ER -