Gradient nanostructures for interfacing microfluidics and nanofluidics

Han Cao, Jonas O. Tegenfeldt, Robert H. Austin, Stephen Y. Chou

Research output: Contribution to journalArticlepeer-review

199 Scopus citations


It is difficult to introduce long genomic DNA molecules into nanometer scale fluidic channels directly from the macroscale world because of the steep entropic barrier caused by necessary stretching of the polymer. We present a very simple technique using optical lithography to fabricate continuous spatial gradient structures which smoothly narrow the cross section of a volume from the micron to the nanometer length scale, greatly reducing the local entropic barrier to nanochannel entry. This technique, diffraction gradient lithography, can be very valuable for the fabrication of micro/nano total analysis systems.

Original languageEnglish (US)
Pages (from-to)3058-3060
Number of pages3
JournalApplied Physics Letters
Issue number16
StatePublished - Oct 14 2002

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)


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